Qiaoyu Zheng (郑乔予)
Hello! I am a PhD student at Shanghai Jiao Tong University, advised by Prof. Weidi Xie. I graduated with a bachelor's degree in Computer Science from the School of Electronic Information and Electrical Engineering at Shanghai Jiao Tong University in June 2023.
My current research interest focuses on Artificial Intelligence for Healthcare (AI4Health). I am looking forward to the day when AI in healthcare can truly benefit humanity.
Qiaoyu Zheng

Research

RadABench
How Well Can Modern LLMs Act as Agent Cores in Radiology Environments?
EMNLP 2026, Main Conference
We present RadA-BenchPlat, a two-layer benchmark for radiology agents: a synthetic layer with 2.2k clinician-verified records, 24.2k QA pairs and 10 tool categories, and a real-environment layer pairing 165 2D/3D cases with executable tools. High completion rates under idealized settings do not carry over to real execution, while prompting strategies and on-the-fly synthesis of missing tools substantially narrow the gap.
MedSR-Copilot
A PRISMA-Aligned Agentic Framework for Medical Systematic Reviews and Evidence Synthesis
medRxiv preprint, 2026
We introduce MedSR-Copilot, a PRISMA-aligned multi-agent copilot that automates medical systematic reviews end-to-end—literature retrieval, coarse-to-fine screening, data extraction, risk-of-bias assessment and evidence synthesis—together with MedSR-Bench for end-to-end evaluation. It attains 63.6% human-aligned conclusions, and as a copilot cuts review time by 64.9% while raising conclusion accuracy by 27.4 points.
OpenPheno
Phenotypic Bioactivity Prediction as Open-set Biological Assay Querying
Yuze Sun*, Xiaoman Zhang*, Qiaoyu Zheng, Hanzheng Li, Jianming Zhang, Liang Hong, Yanfeng Wang†, Ya Zhang†, Weidi Xie†
bioRxiv preprint, 2026
We present OpenPheno, a multimodal foundation model that reframes bioactivity prediction as open-set visual-language question answering. Pairing chemical structures and Cell Painting phenotypic profiles with natural-language assay descriptions enables a "profile once, predict many" paradigm, reaching 0.75 mean AUROC zero-shot on 54 unseen assays and holding 0.66 when both compounds and assays are novel.
DiagAgent
Evolving Interactive Diagnostic Agents in a Virtual Clinical Environment
Pengcheng Qiu*, Chaoyi Wu*, Junwei Liu*, Qiaoyu Zheng, Yusheng Liao, Haowen Wang, Yun Yue, Qianrui Fan, Shuai Zhen, Jian Wang, Jinjie Gu, Yanfeng Wang, Ya Zhang†, Weidi Xie†
arXiv preprint, 2025
We train LLMs as interactive diagnostic agents with end-to-end multi-turn reinforcement learning. DiagGym, a diagnostics world model built from electronic health records, serves as a virtual clinical environment for closed-loop training, and DiagBench supplies 2.2K physician-validated cases with 3.3K rubrics. The resulting DiagAgent outperforms 11 state-of-the-art LLMs and 2 prompt-engineered agents in both in-domain and out-of-domain settings.
Deep-DxSearch
End-to-End Agentic RAG System Training for Traceable Diagnostic Reasoning
arXiv preprint, 2025
We introduce Deep-DxSearch, an end-to-end agentic RAG system trained with reinforcement learning for traceable diagnostic reasoning. Our framework addresses knowledge gaps and hallucinations in medical LLMs by constructing a large-scale medical retrieval corpus and using the LLM as a core agent with tailored rewards. Deep-DxSearch consistently outperforms prompt-engineering and training-free RAG approaches, achieving substantial gains over GPT-4o, DeepSeek-R1, and other medical frameworks for both common and rare disease diagnosis.
M3Builder
M³Builder: A Multi-Agent System for Automated Machine Learning in Medical Imaging
Jinghao Feng*, Qiaoyu Zheng*, Chaoyi Wu, Ziheng Zhao, Ya Zhang, Yanfeng Wang, Weidi Xie†
MICCAI Workshop, 2025, Oral
We present M³Builder, an LLM-powered multi-agent system for autonomous end-to-end medical imaging AI model training—the first to automate ML in medical imaging, lowering the threshold for clinicians to develop and apply AI models, and promoting the widespread adoption of AI tools in real clinical scenarios.
RP3D-Diag
Large-scale Long-tailed Disease Diagnosis on Radiology Images
Nature Communications, 2024
We build up an academically accessible, large-scale diagnostic dataset, present a knowledge enhanced model architecture that enables processing arbitrary number of input scans from various imaging modalities, and initialize a new benchmark for multi-modal multi-anatomy long-tailed diagnosis. Our method shows superior results and serves as a pre-trained model that can be finetuned to benefit diagnosis on various external datasets.
GPT4V Evaluation
Can GPT-4V(ision) Serve Medical Applications? Case Studies on GPT-4V for Multimodal Medical Diagnosis
Chaoyi Wu*, Jiayu Lei*, Qiaoyu Zheng*, Weike Zhao*, Weixiong Lin*, Xiaoman Zhang*, Xiao Zhou*, Ziheng Zhao*, Ya Zhang, Yanfeng Wang, Weidi Xie†
Technical Report, 2023
We present recent efforts on assessing GPT-4V for multimodal medical diagnosis through case studies, covering 17 human body systems across 8 clinical imaging modalities, including radiology and pathology.